Document Details
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Document Type |
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Article In Journal |
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Document Title |
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Global genetic variation of select opiate metabolism genes in self-reported healthy individuals Global genetic variation of select opiate metabolism genes in self-reported healthy individuals |
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Document Language |
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English |
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Abstract |
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CYP2D6 is a key pharmacogene encoding an enzyme impacting poor, intermediate, extensive and ultrarapid phase I metabolism
of many marketed drugs. The pharmacogenetics of opiate drug metabolism is particularly interesting due to the relatively high
incidence of addiction and overdose. Recently, trans-acting opiate metabolism and analgesic response enzymes (UGT2B7, ABCB1,
OPRM1 and COMT) have been incorporated into pharmacogenetic studies to generate more comprehensive metabolic profiles of
patients. With use of massively parallel sequencing, it is possible to identify additional polymorphisms that fine tune, or redefine,
previous pharmacogenetic findings, which typically rely on targeted approaches. The 1000 Genomes Project data were analyzed to
describe population genetic variation and statistics for these five genes in self-reported healthy individuals in five global super- and
26 sub-populations. Findings on the variation of these genes in various populations expand baseline understanding of
pharmacogenetically relevant polymorphisms for future studies of affected cohorts. |
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ISSN |
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1470-269X |
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Journal Name |
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The Pharmacogenomics Journal |
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Volume |
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1 |
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Issue Number |
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1 |
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Publishing Year |
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1438 AH
2017 AD |
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Article Type |
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Article |
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Added Date |
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Tuesday, May 16, 2017 |
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Researchers
| FR Wendt | Wendt, FR | Investigator | Doctorate | |
| G Pathak | Pathak, G | Researcher | Doctorate | |
| A Sajantila | Sajantila, A | Researcher | Doctorate | |
| R Chakraborty | Chakraborty, R | Researcher | Doctorate | |
| B Budowle | Budowle, B | Researcher | Doctorate | |
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